Oxytocin Acetate 2mg
$19.8
$34.06
Description Oxytocin, a versatile neuropeptide, plays a crucial role in various physiological and psychological processes beyond its well-known reproductive functions. It is synthesized in the hypothalamus and released into the bloodstream, where it binds to specific receptors in the brain and other organs. Neurological Effects Social Bonding: Oxytocin enhances social bonding, trust, and empathy by modulating activity in brain regions like the amygdala and prefrontal cortex. Stress Reduction: It helps reduce stress and anxiety by downregulating the stress hormone cortisol. Pain Modulation: Oxytocin can alleviate pain by interacting with opioid and serotonin systems. Cognitive Function: It may improve cognitive functions like memory and learning by influencing synaptic plasticity. Physiological Effects Reproductive Functions: Oxytocin plays a pivotal role in childbirth, lactation, and pair bonding. Cardiovascular Health: It can help regulate blood pressure and blood flow. Gastrointestinal Function: Oxytocin influences gut motility and inflammation. Metabolic Regulation: It may impact energy metabolism and appetite control. In summary, oxytocin is a multifaceted hormone with a wide range of physiological and psychological effects. Its ability to influence social behavior, stress response, pain perception, and various physiological processes highlights its importance in human health and well-being. References Faraji, J., Karimi, M., Soltanpour, N., Moharrerie, A., Rouhzadeh, Z., Lotfi, H., Hosseini, S. A., Jafari, S. Y., Roudaki, S., Moeeini, R., & Metz, G. A. (2018). Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking. eLife, 7, e40262.https://doi.org/10.7554/eLife.40262. Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014). Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration. Nature communications, 5, 4082.https://doi.org/10.1038/ncomms5082. Hong, S. M., Ko, J. K., Moon, J. J., & Kim, Y. R. (2021). Oxytocin: A Potential Therapeutic for Obesity. Journal of obesity & metabolic syndrome, 30(2), 115–123.https://doi.org/10.7570/jomes20098. Espinoza, S. E., Lee, J. L., Wang, C. P., Ganapathy, V., MacCarthy, D., Pascucci, C., Musi, N., & Volpi, E. (2021). Intranasal Oxytocin Improves Lean Muscle Mass and Lowers LDL Cholesterol in Older Adults with Sarcopenic Obesity: A Pilot Randomized Controlled Trial. Journal of the American Medical Directors Association, 22(9), 1877–1882.e2.https://doi.org/10.1016/j.jamda.2021.04.015. Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2020). The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis. Journal of neuroendocrinology, 32(4), e12805.https://doi.org/10.1111/jne.12805. Edwards, M. M., Nguyen, H. K., Herbertson, A. J., Dodson, A. D., Wietecha, T., Wolden-Hanson, T., Graham, J. L., O’Brien, K. D., Havel, P. J., & Blevins, J. E. (2021). Chronic hindbrain administration of oxytocin elicits weight loss in male diet-induced obese mice. American journal of physiology. Regulatory, integrative and comparative physiology, 320(4), R471–R487.https://doi.org/10.1152/ajpregu.00294.2020. Niu, J., Tong, J., & Blevins, J. E. (2021). Oxytocin as an Anti-obesity Treatment. Frontiers in neuroscience, 15, 743546.https://doi.org/10.3389/fnins.2021.743546. Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011). Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging, 3(12), 1169–1177.https://doi.org/10.18632/aging.100408. Pflimlin, E., Zhou, Z., Amso, Z., Fu, Q., Lee, C., Muppiddi, A., Joseph, S. B., Nguyen-Tran, V., & Shen, W. (2020). Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects. Journal of medicinal chemistry, 63(1), 382–390.https://doi.org/10.1021/acs.jmedchem.9b01862. Erdenebayar, O., Kato, T., Kawakita, T., Kasai, K., Kadota, Y., Yoshida, K., Iwasa, T., & Irahara, M. (2021). Effects of peripheral oxytocin administration on body weight, food intake, adipocytes, and biochemical parameters in peri- and postmenopausal female rats. Endocrine journal, 68(1), 7–16.https://doi.org/10.1507/endocrj.EJ19-0586. Yamamoto, S., Noguchi, H., Takeda, A., Arakaki, R., Uchishiba, M., Imaizumi, J., Minato, S., Kamada, S., Kagawa, T., Yoshida, A., Kawakita, T., Yamamoto, Y., Yoshida, K., Kon, M., Shinohara, N., & Iwasa, T. (2022). Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats. International journal of molecular sciences, 23(15), 8207.https://doi.org/10.3390/ijms23158207. Roberts, Z. S., Wolden-Hanson, T., Matsen, M. E., Ryu, V., Vaughan, C. H., Graham, J. L., Havel, P. J., Chukri, D. W., Schwartz, M. W., Morton, G. J., & Blevins, J. E. (2017). Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats. American journal of physiology. Regulatory, integrative and comparative physiology, 313(4), R357–R371.https://doi.org/10.1152/ajpregu.00169.2017. Blevins, J. E., Thompson, B. W., Anekonda, V. T., Ho, J. M., Graham, J. L., Roberts, Z. S., Hwang, B. H., Ogimoto, K., Wolden-Hanson, T., Nelson, J., Kaiyala, K. J., Havel, P. J., Bales, K. L., Morton, G. J., Schwartz, M. W., & Baskin, D. G. (2016). Chronic CNS oxytocin signaling preferentially induces fat loss in high-fat diet-fed rats by enhancing satiety responses and increasing lipid utilization. American journal of physiology. Regulatory, integrative and comparative physiology, 310(7), R640–R658.https://doi.org/10.1152/ajpregu.00220.2015. Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012). Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. American journal of physiology. Endocrinology and metabolism, 302(1), E134–E144.https://doi.org/10.1152/ajpendo.00296.2011. Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2020). The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis. Journal of neuroendocrinology, 32(4), e12805.https://doi.org/10.1111/jne.12805. Blevins, J. E., & Ho, J. M. (2013). Role of oxytocin signaling in the regulation of body weight. Reviews in endocrine & metabolic disorders, 14(4), 311–329.https://doi.org/10.1007/s11154-013-9260-x. Yuan, J., Zhang, R., Wu, R., Gu, Y., & Lu, Y. (2020). The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis. Molecular and cellular endocrinology, 514, 110903.https://doi.org/10.1016/j.mce.2020.110903.
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